In the general sense, the absolute velocity of any object through space is not a meaningful question according to Einstein's special theory of relativity, which declares that there is no "preferred" inertial frame of reference in space with which to compare the Galaxy's motion. (Motion must always be specified with respect to another object.)

Astronomers believe the Milky Way is moving at approximately 600 km per second relative to the observed locations of other nearby galaxies. Most recent estimates range from 130 km/s to 1,000 km/s. If the Galaxy is moving at 600 km/s, Earth travels 51.84 million km per day, or more than 18.9 billion km per year, about 4.5 times its closest distance from Pluto. The Galaxy is thought to be moving in the direction of the constellation Hydra.^{[citation needed]} The Local Group (which contains the Galaxy) is thought to be gravitationally bound to the Virgo Cluster of galaxies: although they are moving away from each other at 967 km/s as part of the Hubble flow, the velocity is less than would be expected given the 16.8 million pc distance due to the gravitational attraction between the Local Group and the Virgo Cluster.

Another reference frame is provided by the cosmic microwave background (CMB). The Milky Way is moving at around 552 km/s with respect to the photons of the CMB, toward 10.5 right ascension, -24° declination (J2000 epoch, near the center of Hydra). This motion is observed by satellites such as the Cosmic Background Explorer (COBE) and the Wilkinson Microwave Anisotropy Probe (WMAP) as a dipole contribution to the CMB, as photons in equilibrium in the CMB frame get blue-shifted in the direction of the motion and red-shifted in the opposite direction.